The influence of amphiphilic quaternary ammonium palmitoyl glycol chitosan (GCPQ) polymer composition on oil-loaded nanocapsule architecture
Non-linear mathematical models (Particle size (nm) = 466.05 - 5.64DP - 6.52DQ + 0.13DQ<sup>2</sup> - 0.03 MW<sup>2</sup> - 14.48cHLB + 0.48cHLB<sup>2</sup>) were derived to predict the nanoparticle sizes (R<sup>2</sup> = 0.998, R<sup>2</sup><sub>adj</sub> = 0.995). Smaller nanoparticle sizes (148-157 nm) were obtained at high DP, DQ, and cHLB values, in which DP was the main independent variable responsible for nanoparticle size. Single or multiple-oil cores with small particles stabilizing polymer shells could be observed depending on the oil volume. Nanoparticle architectures, especially the nature of the oil-core(s), were driven by the DP, DQ, cHLB, and oil concentration. Here, we have developed a predictive model that may be applied to understand the nanoarchitecture of oil-loaded GCPQ-nanoparticles.
Authors
- Andreas G. Schätzlein (ORCID: https://orcid.org/0000-0003-3907-6603)
- Rui M. Lopes (ORCID: https://orcid.org/0000-0001-6904-224X)
- Ijeoma F. Uchegbu
- Ryan Mellor (ORCID: https://orcid.org/0000-0002-0677-5603)
- Francisco Humberto Xavier Júnior (ORCID: https://orcid.org/0000-0001-8238-3380)
Institutions
- Universidade Federal da Paraíba (BR)
- St Mark's Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Journal of Colloid and Interface Science
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1016/j.jcis.2024.08.250
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior