Identification of biomarker associated with Trop2 in breast cancer: implication for targeted therapy
MAP3K1, NOTCH2, PTEN and MAGI2 mutations were significantly different between Trop2 medium expression and Trop2 high expression BC patients. The effects of Trop2 mutation on the expression, variation, methylation, and phosphorylation of other genes were comprehensively revealed. High expression level of Trop2 and Trop2 mutation were predictive biomarker for poor prognosis and targeted therapy in BC.
Authors
- Jianguo Lai (ORCID: https://orcid.org/0000-0002-0120-0245)
- Zanmei Xu (ORCID: https://orcid.org/0000-0001-5012-6494)
- Yongqi Ren (ORCID: https://orcid.org/0000-0002-3444-5302)
- Xiaofang Qi
- Ning Liao (ORCID: https://orcid.org/0000-0002-1780-5652)
- Shuxuan Deng
- Jiyuan Cao
- Mian Xu
Institutions
- Shantou University (CN)
- Shantou University Medical College (CN)
- Guangdong Academy of Medical Sciences (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1007/s12672-024-01261-0
- Citations
- 4
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- National Natural Science Foundation of China
- Guangdong Medical Research Foundation
- Guangdong Provincial People's Hospital
- Guangzhou Municipal Science and Technology Project