Wearable bio-adhesive metal detector array (BioMDA) for spinal implants
Dynamic tracking of spinal instrumentation could facilitate real-time evaluation of hardware integrity and in so doing alert patients/clinicians of potential failure(s). Critically, no method yet exists to continually monitor the integrity of spinal hardware and by proxy the process of spinal arthrodesis; as such hardware failures are often not appreciated until clinical symptoms manifest. Accordingly, herein, we report on the development and engineering of a bio-adhesive metal detector array (BioMDA), a potential wearable solution for real-time, non-invasive positional analyses of osseous implants within the spine. The electromagnetic coupling mechanism and intimate interfacial adhesion enable the precise sensing of the metallic implants position without the use of radiation. The customized decoupling models developed facilitate the precise determination of the horizontal and vertical positions of the implants with incredible levels of accuracy (e.g., <0.5 mm). These data support the potential use of BioMDA in real-time/dynamic postoperative monitoring of spinal implants.
Authors
- Hongwei Chu
- Xinge Yu (ORCID: https://orcid.org/0000-0003-0522-1171)
- Joshua D. Bernstock (ORCID: https://orcid.org/0000-0002-7814-3867)
- Muhamed Hadzipasic
- Yiyuan Yang (ORCID: https://orcid.org/0000-0003-1262-354X)
- Giovanni Battista Traverso (ORCID: https://orcid.org/0000-0001-7851-4077)
- Kuanming Yao (ORCID: https://orcid.org/0000-0001-8744-8892)
- Jingkun Zhou (ORCID: https://orcid.org/0000-0001-5394-4388)
- Woo‐Young Park (ORCID: https://orcid.org/0000-0003-2250-3613)
- Xingcan Huang (ORCID: https://orcid.org/0000-0003-4210-2470)
- Lung Chow (ORCID: https://orcid.org/0000-0001-5670-1031)
- Rui Shi (ORCID: https://orcid.org/0000-0002-4221-0239)
- Kewang Nan (ORCID: https://orcid.org/0000-0002-2745-0656)
- Xinyu Pan (ORCID: https://orcid.org/0000-0002-0281-7626)
- Ya Huang (ORCID: https://orcid.org/0000-0002-0965-8226)
- Shengxin Jia (ORCID: https://orcid.org/0000-0002-6998-3872)
- Zhenlin Chen (ORCID: https://orcid.org/0000-0003-2100-1363)
- Qing’ao Qu
- Yuyu Gao (ORCID: https://orcid.org/0000-0002-2000-5410)
- Ganesh M. Shankar (ORCID: https://orcid.org/0009-0006-5203-8619)
- Zhan Gao (ORCID: https://orcid.org/0000-0002-8465-4292)
- Qiang Zhang (ORCID: https://orcid.org/0000-0002-2707-0258)
- Jian Li (ORCID: https://orcid.org/0000-0002-9768-0932)
- Hu Li (ORCID: https://orcid.org/0000-0003-1050-8441)
- Binbin Zhang (ORCID: https://orcid.org/0009-0004-6595-9367)
- Pengcheng Wu (ORCID: https://orcid.org/0000-0002-7990-4234)
- Guangyao Zhao (ORCID: https://orcid.org/0000-0002-5664-4898)
- Zongze Li (ORCID: https://orcid.org/0000-0002-4807-1890)
- Yue Hu (ORCID: https://orcid.org/0000-0002-3846-9096)
- Dengfeng Li (ORCID: https://orcid.org/0000-0002-8875-6974)
- Xiao Bai
- Zhi-Yuan Li (ORCID: https://orcid.org/0000-0001-9424-8936)
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Department of Health (CN)
- Harvard University (US)
- City University of Hong Kong (HK)
- Massachusetts General Hospital (US)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Massachusetts Institute of Technology (US)
- Zhejiang University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1038/s41467-024-51987-2
- Citations
- 10
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- City University of Hong Kong
- National Natural Science Foundation of China