Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction
An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF<sub>2</sub>SO<sub>2</sub>Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.
Authors
- Zheng Fang (ORCID: https://orcid.org/0000-0002-3209-4713)
- Yu Sun (ORCID: https://orcid.org/0000-0003-4269-7187)
- G.‐W. WANG
- Chunjie Ni (ORCID: https://orcid.org/0000-0003-1479-5484)
- Ying Liu (ORCID: https://orcid.org/0000-0001-6718-7381)
- Xiaojuan Xu (ORCID: https://orcid.org/0000-0003-1869-930X)
- Dong Zhang (ORCID: https://orcid.org/0000-0001-7601-9443)
- Qingzhi Ji (ORCID: https://orcid.org/0000-0003-0377-8718)
Institutions
- Nanjing Tech University (CN)
- Yancheng Teachers University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1021/acs.joc.4c01528
- Citations
- 5
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- Basic Research Program of Jiangsu Province
- Natural Science Research of Jiangsu Higher Education Institutions of China