Solvent‐Free Dehydrogenative C−H Chalcogenations of Pyrazolones Using Mechanochemistry
Abstract A mechanochemical cross‐dehydrogenative coupling reaction of pyrazolones with thiols using ball milling is described. Benzeneselenol and dichalcogenide substrates are also compatible under mild reaction conditions, yielding up to 99 %. Notable features of this reaction include its metal‐ and solvent‐free, wide substrate scope and good functional group tolerance. Preliminary mechanistic investigations suggest that a radical pathway is likely involved in this C−H chalcogenation reaction.
Authors
- Zihan Yu (ORCID: https://orcid.org/0009-0007-2465-4067)
- Linghui Gu (ORCID: https://orcid.org/0000-0001-6786-5947)
- Jun‐Long Li (ORCID: https://orcid.org/0000-0002-4700-0142)
- Zheyu Li (ORCID: https://orcid.org/0009-0008-4952-8523)
- Tao Zheng (ORCID: https://orcid.org/0000-0002-1820-1762)
- Qilin Gu
- Wenbo Ma (ORCID: https://orcid.org/0000-0002-4767-7209)
Institutions
- Chengdu University (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1002/ajoc.202400353
- Citations
- 4
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 1.00