Characteristics of Post-Surgery Treatment in Gastric Perforation Patient with Ceftriaxone and Metronidazole

Background: Gastric perforation is one of the causes for acute pain abdomen with a high mortality rate of 10-40%. Surgical therapy and antibiotic therapy should be a part of management in these patients to reduce the number of mortality. Antibiotic therapy provided is a combination of ceftriaxone and metronidazole. Aim: The aim of this study is the characteristics of gastric perforation in patients using an antibiotic combination of ceftriaxone and metronidazole. Materials and Methods: A retrospective study design was used by collecting medical records of inpatient surgery between the January 2010 to December 2014 in Dr. Hasan Sadikin General Hospital, Bandung. The inclusion criteria included patients with or without comorbidities and initial antibiotic therapy using ceftriaxone and metronidazole. Patients who were forced to go home and did not complete therapy were excluded from the study. Parameters used in this study were characteristics based on gender, age, comorbidities, and duration of antibiotic therapy. Results: Based on sex, male frequency (86.7%) was higher than females (13.3%). The largest percentage based on age was in the age category of 55-64 years old (45,2%). 37.8% of patients with gastric perforation had one or more comorbidities. For duration of antibiotic between 5-7 days which was considered appropriate according to guideline showed only 32% patients from this study. In this study, patients with gastric perforation had a mortality of 9.4 %. Conclusions: Gastric perforation was more likely to occur in male and at an older age. Patient had a high chance of comorbid. Gastric perforation made inappropriate days of antibiotic therapy according to the guideline for intra-abdominal infections. Patients with gastric perforation also had a high mortality rate.