Digital cognitive assessments as low‐burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer's spectrum
Performance on digital cognitive assessments predicts progression to mild cognitive impairment at a higher proficiency compared to amyloid beta and tau. Deficits in mnemonic discrimination are indicative of future cognitive decline. Impaired mnemonic discrimination predicts future entorhinal and inferior temporal tau.
Authors
- Craig E.L. Stark (ORCID: https://orcid.org/0000-0002-9334-8502)
- Casey R. Vanderlip (ORCID: https://orcid.org/0000-0002-8233-5829)
Institutions
- National Institutes of Health (US)
- University of California, Irvine (US)
- Irvine University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1002/alz.14154
- Citations
- 15
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 5.78
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- F. Hoffmann-La Roche
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- National Institute on Aging