SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma
Our findings demonstrate that SREBP pathway activation is a critical part of the metabolic reprogramming that occurs in PDAC development and progression. Therefore, targeting the SREBP pathway has significant therapeutic potential.
Authors
- Peter J. Espenshade (ORCID: https://orcid.org/0000-0002-6433-0178)
- Chiaki T. Ishida
- Robert A. Anders (ORCID: https://orcid.org/0000-0002-2363-9072)
- Chune Liu
- Meredith R. McGuire
- Suqi Ke
- Theodore E. Ewachiw (ORCID: https://orcid.org/0000-0002-4712-2203)
- Debaditya Mukhopadhyay (ORCID: https://orcid.org/0009-0002-6510-8007)
- Casie S. Kubota (ORCID: https://orcid.org/0000-0003-2323-7409)
- Stephanie L. Myers (ORCID: https://orcid.org/0000-0002-9625-4886)
- Wei Shao (ORCID: https://orcid.org/0000-0002-5966-4376)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6489-6940)
- Zeshaan A. Rasheed
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0120
- Citations
- 7
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.00