Near-Infrared-Light-Induced Iron(I) Dimer-Enabled Radical Cascade Reactions of Fluoroalkyl Bromides for the Synthesis of Ring-Fused Quinazolinones
The use of an earth-abundant and inexpensive iron complex as a catalyst, coupled with near-infrared (NIR) light as the energy source, for radical reactions with alkyl halides has been far less developed. In this study, we report NIR light-mediated iron(I) dimer-catalyzed radical cascade reactions of fluoroalkyl bromides for the synthesis of ring-fused quinazolinones bearing a difluoromethyl group. In this process, the 3-bromo-1,10-phenanthroline ligand facilitates the reactivity of [CpFe(CO)<sub>2</sub>]<sub>2</sub>, thereby improving the efficiency of the reaction.
Authors
- Xiang‐Yu Chen (ORCID: https://orcid.org/0000-0002-0383-0910)
- Qiang Liu (ORCID: https://orcid.org/0000-0002-8402-029X)
- Zhixiang Wang (ORCID: https://orcid.org/0000-0001-5815-3032)
- Xiao-Di Su (ORCID: https://orcid.org/0009-0003-8100-4926)
- Jin‐Tang Cheng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Binzhou People's Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1021/acs.orglett.4c03087
- Citations
- 13
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences
- University of Chinese Academy of Sciences
- Fundamental Research Funds for the Central Universities
- Beijing National Laboratory for Molecular Sciences