Gender and melanoma subtype‐based prognostic implications of <i>MUC16</i> and <i>TTN</i> co‐occurrent mutations in melanoma: A retrospective multi‐study analysis
TTN mutations are a potential marker of poor prognosis in melanoma, which is amplified in the presence of concurrent MUC16 mutations. ALM patients with neither gene mutations had worse prognosis, suggesting a protective effect of having both MUC16 and TTN mutations. Only MUC16 mutations conferred a worse prognosis for MUP patients. Comprehensive genetic profiling in melanoma patients may facilitate personalized treatment strategies to optimize patient outcomes.
Authors
- Nilesh Kodali (ORCID: https://orcid.org/0000-0003-2092-9469)
- Shari R. Lipner (ORCID: https://orcid.org/0000-0001-5913-9304)
- Robert A. Schwartz (ORCID: https://orcid.org/0000-0003-3036-3825)
- Abhijit Bhattaru (ORCID: https://orcid.org/0000-0002-1383-1992)
- Simona Alomary (ORCID: https://orcid.org/0009-0002-5643-3377)
- Ahmed Eldaboush (ORCID: https://orcid.org/0009-0009-6699-5956)
Institutions
- Rutgers, The State University of New Jersey (US)
- Cornell University (US)
- Weill Cornell Medicine (US)
- Rutgers New Jersey Medical School (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/cam4.70199
- Citations
- 5
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.41