Association of Declining Prostate-specific Antigen Levels with Clinical Outcomes in Patients with Metastatic Castration-resistant Prostate Cancer Receiving [177Lu]Lu-PSMA-617 in the Phase 3 VISION Trial
The magnitude of PSA decline was associated with improvement in clinical and patient-reported outcomes in patients with mCRPC receiving <sup>177</sup>Lu-PSMA-617 plus SoC in VISION. PSA decline therefore appears to have a prognostic value during <sup>177</sup>Lu-PSMA-617 treatment in this population.
Authors
- Ken Herrmann (ORCID: https://orcid.org/0000-0002-9662-7259)
- Scott T. Tagawa (ORCID: https://orcid.org/0000-0003-2777-8587)
- Karim S. Fizazi (ORCID: https://orcid.org/0000-0002-6068-9474)
- Bernd Joachim Krause (ORCID: https://orcid.org/0000-0002-2572-4131)
- Michael J. Morris (ORCID: https://orcid.org/0000-0002-9454-0096)
- Osvaldo Mirante
- Kambiz Rahbar (ORCID: https://orcid.org/0000-0002-4591-4055)
- Andrew J. Armstrong (ORCID: https://orcid.org/0000-0001-7012-1754)
- Tomasz M. Beer (ORCID: https://orcid.org/0000-0001-5600-9993)
- Fred Saad (ORCID: https://orcid.org/0000-0003-2986-5617)
- Johann Sebastian De Bono (ORCID: https://orcid.org/0000-0002-2034-595X)
- Oliver A. Sartor (ORCID: https://orcid.org/0000-0002-8777-7343)
- Jiwen Wu
- Kim Chi
Institutions
- Novartis (Switzerland) (CH)
- Memorial Sloan Kettering Cancer Center (US)
- University of British Columbia (CA)
- Institute of Cancer Research (GB)
- Oregon Health & Science University (US)
- Cornell University (US)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- University Hospital Münster (DE)
- Prostate Cancer Research (GB)
- Novartis (United States) (US)
- Essen University Hospital (DE)
- Royal Marsden Hospital (GB)
- Mayo Clinic in Arizona (US)
- Weill Cornell Medicine (US)
- University of Rostock (DE)
- Université de Montréal (CA)
Publication Details
- Journal
- European Urology
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1016/j.eururo.2024.08.021
- Citations
- 15
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 6.28
Funders
- Medical Research Council