Triflic Anhydride-Mediated Approach to Furo[3,2-<i>b</i>]furans from Diacetonide Protected Furanoses

Trifluoromethanesulfonic anhydride (Tf₂O) exhibits excellent reactivity as an electrophile, serving as a highly versatile reagent in diverse chemical transformations. Herein, we report an operationally simple, efficient, unique, and practical one-step strategy for synthesizing diverse valuable structures bearing furo[3,2-<i>b</i>]furans core leveraging Tf₂O's promoted reactivity of nitriles with diacetonide protected furanose. Furthermore, we demonstrate the potential of furo[3,2-<i>b</i>]furan as a precursor for complex structures through 1,3-dipolar cycloaddition.