Pro‐ and anti‐inflammatory cytokines mediate the progression of severe anemia in malaria‐infected children: A prospective study
Parasite density was the principal predictor of the cytokine levels, as parasitemia positively associated with IL-10, GM-CSF, IL-6, IL-1β, IFN-ɣ, and TNF-α, but negatively associated with IL-3 and TGF-β. Malaria is associated with enhanced secretion of pro- and anti-inflammatory cytokines in Ghanaian children. Inflammatory cytokines may be involved in the development of severe malarial anemia in children. However, IL-3 and TGF-β may offer protection against severe malarial anemia.
Authors
- Gabriel Abbam (ORCID: https://orcid.org/0000-0002-0408-6126)
- Emmanuel Appiah‐Kubi (ORCID: https://orcid.org/0000-0002-2783-0202)
- Isaac Adjei (ORCID: https://orcid.org/0000-0002-8730-5899)
- Ejike Felix Chukwurah (ORCID: https://orcid.org/0000-0001-5485-3453)
- Samira Daud (ORCID: https://orcid.org/0000-0003-0133-1760)
- Charles A. Derigubah (ORCID: https://orcid.org/0000-0003-1519-3530)
- Richard Vikpebah Duneeh (ORCID: https://orcid.org/0000-0003-2314-5811)
- Samuel Kwasi Appiah
- Charles Nkansah (ORCID: https://orcid.org/0000-0001-6986-9976)
- Moses Banyeh (ORCID: https://orcid.org/0000-0003-3594-6077)
- Felix Osei‐Boakye (ORCID: https://orcid.org/0000-0001-5126-7424)
- Muniru Mohammed Tanko (ORCID: https://orcid.org/0000-0002-0487-8465)
- Miigbat P. Libatin
- Mary K. Missah
- Pagnaa G. Abdul‐Rauf
- Zacharia A. Ofori
- George B. Fosu
- Sandra Segnitome
- Bright Boakye (ORCID: https://orcid.org/0009-0009-7537-3913)
- Samsiyatu Abdulai (ORCID: https://orcid.org/0009-0001-2166-7918)
- Theophilus B. Antwi
- Stephany Adda
- Birago Boateng
- Amponsah Amishadas Mensah
- A. Haruna
- Madina Ahmed
Institutions
- University of Health and Allied Sciences (GH)
- Tamale Teaching Hospital (GH)
- Sunyani Technical University (GH)
- Bolgatanga Technical University
- University for Development Studies (GH)
- Ebonyi State University (NG)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/iid3.70013
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 2.17