Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers
Better cardiovascular health associates with slower cognitive decline in frontotemporal lobar degeneration (FTLD). Lifestyle relates to the accumulation of frontal white matter hyperintensities in FTLD. More optimal cardiovascular health associates with greater baseline frontotemporal lobe volume. Optimized cardiovascular health relates to more favorable outcomes in genetic dementia.
Authors
- Lawrence S. Honig (ORCID: https://orcid.org/0000-0002-9703-2265)
- Irene Litvan (ORCID: https://orcid.org/0000-0002-3485-3445)
- Hilary W. Heuer (ORCID: https://orcid.org/0000-0002-3776-1685)
- Adam M. Staffaroni (ORCID: https://orcid.org/0000-0002-3903-9805)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Adam L. Boxer (ORCID: https://orcid.org/0000-0002-1215-5064)
- Anna M. VandeBunte (ORCID: https://orcid.org/0000-0002-5167-3358)
- Kimiko Domoto‐Reilly (ORCID: https://orcid.org/0000-0002-7396-1633)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Katya Rascovsky
- Rowan Saloner (ORCID: https://orcid.org/0000-0002-1351-6183)
- Julie A. Fields (ORCID: https://orcid.org/0000-0002-1282-9866)
- Kaitlin Blackstone Casaletto (ORCID: https://orcid.org/0000-0001-5000-7604)
- Ian R. Mackenzie (ORCID: https://orcid.org/0000-0003-3875-2972)
- Kristine S. Yaffe (ORCID: https://orcid.org/0000-0003-0919-3825)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Ging‐Yuek Robin Hsiung (ORCID: https://orcid.org/0000-0002-8017-0856)
- Andrea Bozoki (ORCID: https://orcid.org/0000-0002-4899-9381)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Bonnie Wong (ORCID: https://orcid.org/0000-0001-9973-3009)
- Douglas R Galasko (ORCID: https://orcid.org/0000-0001-6195-3241)
- Leah K. Forsberg (ORCID: https://orcid.org/0000-0003-4086-9598)
- Brian S. Appleby (ORCID: https://orcid.org/0000-0003-2275-3292)
- Mario F. Mendez (ORCID: https://orcid.org/0000-0001-6441-7989)
- Nupur Ghoshal (ORCID: https://orcid.org/0000-0002-6680-6731)
- Emily W. Paolillo (ORCID: https://orcid.org/0000-0003-4188-6998)
- Hyun Woo Lee (ORCID: https://orcid.org/0000-0002-6879-9686)
- Allison Snyder (ORCID: https://orcid.org/0000-0002-1857-928X)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-1206-404X)
- Peter Pressman (ORCID: https://orcid.org/0000-0003-1760-1286)
- Ryan Darby
- Eliana Marisa Ramos (ORCID: https://orcid.org/0009-0003-7982-4415)
- Maria Belen Pasqual
- Howard J. Rosen
Institutions
- University of North Carolina at Chapel Hill (US)
- University of British Columbia Hospital (CA)
- Houston Methodist (US)
- Mayo Clinic (US)
- University of British Columbia (CA)
- Palo Alto University (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- Vanderbilt University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- University Memory and Aging Center (US)
- National Institute of Neurological Disorders and Stroke (US)
- Occupational Cancer Research Centre (CA)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1002/alz.14172
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging