The cytoskeleton dynamics-dependent LINC complex in periodontal ligament stem cells transmits mechanical stress to the nuclear envelope and promotes YAP nuclear translocation
Our study confirmed that appropriate TS could promote PDLSCs proliferation and periodontal tissue remodeling through the mechanically driven F-actin/LINC complex/YAP axis, which could provide theoretical guidance for seed cell expansion and for promoting healthy and effective tooth movement in clinical practice.
Authors
- Xuehuan Meng
- Baraa Daraqel (ORCID: https://orcid.org/0000-0002-6398-8920)
- Jinlin Song (ORCID: https://orcid.org/0000-0002-0224-6640)
- Hao Tan (ORCID: https://orcid.org/0000-0002-3447-6600)
- Xinyi He
- Xiang Li (ORCID: https://orcid.org/0000-0002-8095-5485)
- Ming Ye (ORCID: https://orcid.org/0000-0002-7571-2905)
- Guoyin Yang
- Leilei Zheng (ORCID: https://orcid.org/0000-0003-3483-0638)
- Ye Zhu (ORCID: https://orcid.org/0000-0002-7086-0925)
Institutions
- Chongqing University (CN)
- Al-Quds University (PS)
- Chongqing Maternal and Child Health Hospital (CN)
- Stomatological Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing University of Technology (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1186/s13287-024-03884-0
- Citations
- 16
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 5.22
Funders
- National Natural Science Foundation of China