A longitudinal study assessing the impact of elexacaftor/tezacaftor/ivacaftor on gut transit and function in people with cystic fibrosis using magnetic resonance imaging (MRI)
Our findings suggest an improvement in small bowel transit, small bowel response to food and a reduction in colonic volume after starting ETI. These effects may relate to CFTR activation in the small bowel. To our knowledge this is the first study to show a physiological change in GI transit and function in response to CFTR modulator use through imaging studies.
Authors
- H. Barr (ORCID: https://orcid.org/0000-0002-4388-2563)
- Luca Marciani (ORCID: https://orcid.org/0000-0001-9092-4300)
- Neele Dellschaft (ORCID: https://orcid.org/0000-0001-5483-1684)
- Carlos Zagoya (ORCID: https://orcid.org/0000-0002-1822-3750)
- Robert E. Spiller (ORCID: https://orcid.org/0000-0001-6371-4500)
- Iain D. Stewart (ORCID: https://orcid.org/0000-0002-1340-2688)
- Jochen G. Mainz (ORCID: https://orcid.org/0000-0003-3780-7759)
- Alexander Yule (ORCID: https://orcid.org/0000-0002-2666-2673)
- Caroline L. Hoad (ORCID: https://orcid.org/0000-0001-5483-1027)
- Alan R Smyth (ORCID: https://orcid.org/0000-0001-5494-5438)
- Giles Major (ORCID: https://orcid.org/0000-0001-7944-3709)
- Penny Anne Gowland (ORCID: https://orcid.org/0000-0002-4900-4817)
- Christabella Ng (ORCID: https://orcid.org/0000-0001-7243-3014)
- A. Flores Recto
- Florence Lockwood
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Centre Hospitalier Universitaire Vaudois (CH)
- Lung Institute (US)
- NIHR Imperial Biomedical Research Centre (GB)
- Nottingham Biomedical Research Centre (GB)
- Universitätsklinikum Brandenburg an der Havel (DE)
Publication Details
- Journal
- Journal of Cystic Fibrosis
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.jcf.2024.08.001
- Citations
- 5
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Vertex Pharmaceuticals
- Nottingham University Hospitals NHS Trust
- University of Nottingham