Disentangling abiotic and biotic effects of treated wastewater on stream biofilm resistomes enables the discovery of a new planctomycete beta-lactamase
This discovery of a functional planctomycete beta-lactamase ARG is noteworthy, not only because it was the first beta-lactamase to be biochemically characterized from this phylum, but also because it was not detected by standard homology-based ARG tools. In summary, this study conducted a metagenomic analysis of the relative importance of biotic and abiotic factors in the context of WW discharge and their impact on both known and new ARGs in aquatic biofilms. Video Abstract.
Authors
- Serina L. Robinson (ORCID: https://orcid.org/0000-0001-6947-7913)
- Giulia Gionchetta (ORCID: https://orcid.org/0000-0001-9615-882X)
- Helmut Bürgmann (ORCID: https://orcid.org/0000-0002-5651-5906)
- Mustafa Attrah (ORCID: https://orcid.org/0000-0002-7114-0671)
- Kathrin Fenner (ORCID: https://orcid.org/0000-0001-6068-8220)
- Jack van de Vossenberg (ORCID: https://orcid.org/0000-0003-4497-6155)
- Piet N.L. Lens (ORCID: https://orcid.org/0000-0002-5825-878X)
- Mauro Esposito (ORCID: https://orcid.org/0000-0002-0022-2506)
- Milo R. Schärer
Institutions
- Ollscoil na Gaillimhe – University of Galway (IE)
- University of Zurich (CH)
- IHE Delft Institute for Water Education (NL)
- Swiss Federal Institute of Aquatic Science and Technology (CH)
Publication Details
- Journal
- Microbiome
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1186/s40168-024-01879-w
- Citations
- 6
- Primary Topic
- Microbial Community Ecology and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- National Science Foundation
- Biodiversa+
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Eidgenössische Technische Hochschule Zürich
- Vontobel-Stiftung
- Fondation Pierre Mercier pour la Science