Key subdomains of mesencephalic astrocyte-derived neurotrophic factor attenuate myocardial ischemia/reperfusion injury by JAK1/STAT1/NF-κB signaling pathway
These findings highlight MANF and its subdomains as critical regulators of myocardial I/R injury, offering promising therapeutic targets with significant clinical implications for I/R-related diseases.
Authors
- Da Teng
- Chunxiao Wang (ORCID: https://orcid.org/0000-0002-8002-7734)
- Wenjuan Jia (ORCID: https://orcid.org/0000-0003-3381-8506)
- Lei Gong (ORCID: https://orcid.org/0000-0003-4755-1494)
- Haibin Dong (ORCID: https://orcid.org/0000-0002-5851-0578)
- Lin Zhong (ORCID: https://orcid.org/0009-0004-5068-3943)
- Bowen Xu (ORCID: https://orcid.org/0000-0001-5190-8324)
- Jun Yang (ORCID: https://orcid.org/0000-0002-0950-8105)
- Xiaoning Ding
Institutions
- Shanghai Jiao Tong University (CN)
- Yuhuangding Hospital (CN)
- Shanghai Children's Medical Center (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1186/s10020-024-00916-6
- Citations
- 6
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Natural Science Foundation of Shandong Province