Ethical Considerations in the Design and Conduct of Clinical Trials of Artificial Intelligence
This qualitative study identified practical ethical challenges that investigators need to consider and negotiate when conducting AI clinical trials, exemplified by the DR screening use-case. These considerations call for further guidance on where to focus empirical and normative ethical efforts to best support conduct clinical trials of AI and minimize unintended harm to trial participants.
Authors
- Alaa Youssef (ORCID: https://orcid.org/0000-0001-6505-8236)
- Risa M. Wolf (ORCID: https://orcid.org/0000-0001-7674-520X)
- David B. Larson (ORCID: https://orcid.org/0000-0002-1157-5905)
- Michael D. Abràmoff (ORCID: https://orcid.org/0000-0002-3490-0037)
- Ariadne A. Nichol (ORCID: https://orcid.org/0000-0001-9174-9671)
- Nicole Martinez‐Martin (ORCID: https://orcid.org/0000-0001-9345-0462)
- Danton Char (ORCID: https://orcid.org/0000-0002-6064-8971)
Institutions
- University of Iowa (US)
- Johns Hopkins University (US)
- University of Iowa Hospitals and Clinics (US)
- Stanford University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.32482
- Citations
- 28
- Primary Topic
- Artificial Intelligence in Healthcare and Education
- Type
- article
- Field-Weighted Citation Impact
- 3.37