PAF1/HIF1α axis rewires the glycolytic metabolism to fuel aggressiveness of pancreatic cancer
Overall, the results indicate that PAF1/PD2 rewires PC metabolism by interacting with HIF1α to regulate the expression of LDHA.
Authors
- Jesse L. Cox (ORCID: https://orcid.org/0000-0002-4590-7381)
- Rama Krishna Nimmakayala (ORCID: https://orcid.org/0000-0003-4637-4828)
- Moorthy P. Ponnusamy (ORCID: https://orcid.org/0000-0001-5744-193X)
- Sanchita Rauth (ORCID: https://orcid.org/0000-0002-2441-8546)
- Zahraa Wajih Alsafwani (ORCID: https://orcid.org/0009-0006-1795-3598)
- Ayoola O. Ogunleye (ORCID: https://orcid.org/0000-0001-8533-4875)
- Saravanakumar Marimuthu (ORCID: https://orcid.org/0000-0003-3640-5408)
- Surinder K. Batra (ORCID: https://orcid.org/0000-0001-9470-9317)
- Neelanjana Gayen
Institutions
- Nebraska Medical Center (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1186/s40170-024-00354-2
- Citations
- 4
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- University of Nebraska Medical Center
- Nebraska Department of Health and Human Services
- National Institutes of Health