Reduction of butyrate-producing bacteria in the gut microbiome of Japanese patients with pancreatic cancer
The gut and oral microbiome differed between patients with pancreatic cancer and healthy controls, with a notable decrease in butyrate-producing bacteria in the gut microbiome of the patients. This suggests that there may be a distinct microbial signature associated with pancreatic cancer in the Japanese population. Further studies are required to elucidate the microbiome's causal role in this cancer and help develop prognostic markers or targeted therapies.
Authors
- Hiroshi Seno (ORCID: https://orcid.org/0000-0002-8509-8128)
- Kazuyuki Nagai (ORCID: https://orcid.org/0000-0003-2180-2056)
- Takahisa Maruno (ORCID: https://orcid.org/0000-0002-7060-4104)
- Takayuki Anazawa (ORCID: https://orcid.org/0000-0002-7625-5750)
- Yuki Nakanishi (ORCID: https://orcid.org/0000-0001-5493-6312)
- Makoto Sono (ORCID: https://orcid.org/0000-0003-0686-8946)
- Jun Kunisawa (ORCID: https://orcid.org/0000-0003-4901-1125)
- Koji Hosomi
- Haruka Yokota
- Etsuro Hatano (ORCID: https://orcid.org/0000-0003-3407-1918)
- Akihisa Fukuda (ORCID: https://orcid.org/0000-0002-1940-596X)
- Toshihiko Masui (ORCID: https://orcid.org/0000-0002-4001-4824)
- Hiroshi Ohno (ORCID: https://orcid.org/0000-0001-8776-9661)
- Yoshiki Tanaka (ORCID: https://orcid.org/0000-0003-0050-587X)
- Munemasa Nagao (ORCID: https://orcid.org/0000-0003-0789-6623)
- Hiroshi Mori (ORCID: https://orcid.org/0000-0003-0806-7704)
- Satoshi Ogawa (ORCID: https://orcid.org/0000-0003-4970-4212)
- Kei Iimori
Institutions
- National Institute of Genetics (JP)
- Kyoto University (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Senju Pharmaceutical (Japan) (JP)
- Kyoto University Hospital (JP)
Publication Details
- Journal
- Pancreatology
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1016/j.pan.2024.09.002
- Citations
- 7
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology
- Co-creation place formation support program
- Moonshot Research and Development Program