Brain organoid maturation and implantation integration based on electrical signals input
Our findings supported that electrical stimulation could promote the development of cortical organoids. ES-pretreated organoids were better-transplanted donors for strengthening connectivity between grafts and host. Our work presented a new physical approach to regulating organoids, potentially providing a novel translational strategy for functional recovery after brain injury. In the future, the development of 3D flexible electrodes is anticipated to overcome the drawbacks of 2D planar MEA, promisingly achieving multimodal stimulation and long-term recordings of brain organoids.
Authors
- Mengmeng Chen (ORCID: https://orcid.org/0000-0002-7201-0967)
- Dong Ming (ORCID: https://orcid.org/0000-0002-8192-2538)
- Zhe‐Han Chang
- Xiaowang Zhang (ORCID: https://orcid.org/0000-0002-3931-3886)
- Chong Chen (ORCID: https://orcid.org/0000-0003-1329-6501)
- Jianxin Shi (ORCID: https://orcid.org/0000-0001-8606-4707)
- Nan Hu (ORCID: https://orcid.org/0000-0003-1443-2130)
- Xiaohong Li (ORCID: https://orcid.org/0000-0001-5989-6540)
- Jiachen Zuo
- Shuang‐Qing Bao
- Fan Xiu
- Jingjing Wang (ORCID: https://orcid.org/0009-0001-5376-8836)
Institutions
- Tianjin University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1016/j.jare.2024.08.035
- Citations
- 16
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- National Natural Science Foundation of China