Oscillatory-Quality of sleep spindles links brain state with sleep regulation and function
Here, we characterized the dynamics of sleep spindles, focusing on their damping, which we estimated using a metric called oscillatory-Quality (o-Quality), derived by fitting an autoregressive model to electrophysiological signals, recorded from the cortex in mice. The o-Quality of sleep spindles correlates weakly with their amplitude, shows marked laminar differences and regional topography across cortical regions, reflects the level of synchrony within and between cortical networks, is strongly modulated by sleep-wake history, reflects the degree of sensory disconnection, and correlates with the strength of coupling between spindles and slow waves. As most spindle events are highly localized and not detectable with conventional low-density recording approaches, o-Quality thus emerges as a valuable metric that allows us to infer the spread and dynamics of spindle activity across the brain and directly links their spatiotemporal dynamics with local and global regulation of brain states, sleep regulation, and function.
Authors
- Edward Gillen (ORCID: https://orcid.org/0000-0003-2851-3070)
- Peter Achermann (ORCID: https://orcid.org/0000-0002-0208-3511)
- David M. Bannerman (ORCID: https://orcid.org/0000-0002-3024-7595)
- Ross J. Purple (ORCID: https://orcid.org/0000-0003-1061-8106)
- Cristina Blanco‐Duque (ORCID: https://orcid.org/0000-0003-0212-2880)
- Martin C. Kahn (ORCID: https://orcid.org/0000-0002-4211-5020)
- Jean-Philippe Dufour (ORCID: https://orcid.org/0000-0001-9301-2278)
- Vladyslav V. Vyazovskiy (ORCID: https://orcid.org/0000-0002-4336-6681)
- Suraya A Bond (ORCID: https://orcid.org/0000-0001-9200-9739)
- Edward O. Mann (ORCID: https://orcid.org/0000-0002-2468-7148)
- Eckehard Olbrich (ORCID: https://orcid.org/0000-0002-3987-1271)
- Lukas B. Krone (ORCID: https://orcid.org/0000-0002-5535-7221)
Institutions
- University of Bern (CH)
- Vassar College (US)
- Queen Mary University of London (GB)
- ZHAW Zurich University of Applied Sciences (CH)
- University of Zurich (CH)
- University of Cambridge (GB)
- University of Bristol (GB)
- University of Oxford (GB)
- Max Planck Institute for Mathematics in the Sciences (DE)
- CRUK/MRC Oxford Institute for Radiation Oncology (GB)
- UK Dementia Research Institute (GB)
- Science Oxford (GB)
- University College London (GB)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Science Advances
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1126/sciadv.adn6247
- Citations
- 21
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 6.85
Funders
- University of Oxford
- Medical Research Council
- Biotechnology and Biological Sciences Research Council