Trypanosoma cruzi reprograms mitochondrial metabolism within the anterior midgut of its vector Rhodnius prolixus during the early stages of infection
This study is the first to illustrate the response of the digestive epithelium upon contact with T. cruzi, as well as the alteration of mitochondrial sub-proteome by the parasite. This manipulation of the vector's physiology is attributable to the cascade activation of a signaling pathway by the parasite. Understanding the elements of this response, as well as its triggers, could be the foundation for innovative strategies to control the transmission of American trypanosomiasis, such as the development of targeted interventions aimed at disrupting parasite proliferation and transmission within the triatomine vector.
Authors
- Larissa Rezende Vieira (ORCID: https://orcid.org/0000-0003-1596-3953)
- Sabrina Bousbata (ORCID: https://orcid.org/0000-0001-6548-9108)
- Radouane Ouali (ORCID: https://orcid.org/0000-0002-7154-4924)
- Didier Salmon (ORCID: https://orcid.org/0000-0003-0182-8961)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Université Libre de Bruxelles (BE)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1186/s13071-024-06415-1
- Citations
- 2
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Les Amis des Instituts Pasteur à Bruxelles
- Fonds De La Recherche Scientifique - FNRS
- Fédération Wallonie-Bruxelles
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture