Application and Safety of Externally Controlled Metronomic Drug Delivery to the Brain by an Implantable Smart Pump in a Sheep Model
This implantable pump system enables external control of drug output, so that the resulting intraventricular drug concentrations can continuously be maintained within the therapeutic range.
Authors
- Axel H. Schönthal (ORCID: https://orcid.org/0000-0003-0662-5653)
- Eli S. Gang
- Ki-Eun Chang
- Yehoshua Shachar
- Thomas J. Lobl
- Thomas C. Chen (ORCID: https://orcid.org/0000-0002-2183-4667)
- Frank Adell
- Winston H. Wu
- V. Indravudh
Institutions
- University of Southern California (US)
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- USC Norris Comprehensive Cancer Center (US)
- Cardiovascular Research Foundation (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Neurosurgery
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1227/neu.0000000000003155
- Citations
- 3
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.11