Pseudomonas aeruginosa exotoxin A as a novel allergen induced Non-TH2 inflammation in a murine model of steroid-insensitive asthma
PEA is a novel allergen that sensitizes asthmatic patients. Furthermore, mice developed steroid-resistant asthma, characterized by an atypical cytokine profile associated with non-T<sub>H</sub>2 inflammation, only after being sensitized and challenged with rPEA. These findings suggest a potentially significant role for PEA in asthma development, warranting consideration in clinical diagnosis and treatment strategies.
Authors
- Linyi Ma (ORCID: https://orcid.org/0009-0007-3945-6303)
- Ailin Tao (ORCID: https://orcid.org/0000-0002-0584-921X)
- Linmei Li (ORCID: https://orcid.org/0000-0002-8373-133X)
- Jie Yan
- He Lai (ORCID: https://orcid.org/0000-0001-6914-9813)
- Andong He (ORCID: https://orcid.org/0000-0002-2599-5054)
- Xuefeng Zhang (ORCID: https://orcid.org/0000-0002-2831-5747)
- Yongping Liu (ORCID: https://orcid.org/0000-0002-6466-483X)
- Huifang Chen (ORCID: https://orcid.org/0000-0002-4572-5879)
- Yuhe Guo
- Ying He (ORCID: https://orcid.org/0000-0002-1355-2600)
- Linghui Zhou
- Huanping Zhang
- Huancheng Xie
- Yuyi Huang
- Liping Luo
- Xiaokang Sha
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Shanxi Academy of Medical Sciences (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37512
- Citations
- 2
- Primary Topic
- Herbal Medicine Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Natural Science Foundation of China