Association of MME gene polymorphisms with susceptibility to Alzheimer's disease in an Iranian population

There is a strong association between <i>MME</i> gene polymorphisms and susceptibility to AD in the Iranian population. Amyloid-β (Aβ) can serve as a substrate for the NEP metalloendopeptidase, the product of the <i>MME</i> gene. However, the mechanistic understanding of how these genetic variations affect NEP expression, function, and consequently susceptibility to AD, is poorly understood. Further research is required to fully understand the exact implication of <i>MME</i> gene variations on AD, particularly in a larger, ethnicity-diverse population.