Mosquitocidal efficacy and pharmacokinetics of single-dose ivermectin versus three-day dose regimen for malaria vector control compared with albendazole and no treatment: An open-label randomized controlled trial
It is unclear why a single dose led to increased bio-efficacy compared with a triple dose. We recommend trials investigating ivermectin mass drug administrations for malaria control to consider single-dose ivermectin. A single-dose regimen is also expected to present additional operational advantages compared with a 3-day regimen, leading to improved programmatic suitability.
Authors
- Urs Duthaler
- Carlos Chaccour (ORCID: https://orcid.org/0000-0001-9812-050X)
- Kelly Ominde (ORCID: https://orcid.org/0000-0003-4879-7664)
- Felix Hammann (ORCID: https://orcid.org/0000-0003-0658-9330)
- Jonathan Karisa (ORCID: https://orcid.org/0000-0002-3383-6782)
- Caroline Wanjiku (ORCID: https://orcid.org/0000-0003-3861-4190)
- Martha Muturi
- Yvonne Kamau (ORCID: https://orcid.org/0000-0002-8804-2496)
- Mwaganyuma Mwatasa
- Mwanajuma Ngama
- Charlotte Kern (ORCID: https://orcid.org/0000-0003-0388-2435)
- Marta F. Maia (ORCID: https://orcid.org/0000-0003-3302-5610)
- Jane U. Adetifa
- Regina Rabinovich (ORCID: https://orcid.org/0000-0003-1065-0173)
- Mercy Tuwei
- Lawrence Babu
Institutions
- University of Bern (CH)
- Bern University of Applied Sciences (CH)
- University of Basel (CH)
- University Hospital of Bern (CH)
- Kenya Medical Research Institute (KE)
- Department of Biomedicine Basel (CH)
- Barcelona Institute for Global Health (ES)
- Harvard Global Health Institute (US)
- Wellcome Trust (GB)
- Universidad de Navarra (ES)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1016/j.ijid.2024.107236
- Citations
- 8
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 4.34