A home-based exercise programme attenuates fatigue in primary biliary cholangitis: Results from the EXCITED clinical trial
Fatigue is a common symptom in primary biliary cholangitis (PBC), and is linked to cognitive dysfunction, somnolence, and reduced activity. The pathogenesis is multifactorial, and muscle bioenergetic abnormalities have been proposed to contribute. In this study, we show that a home-based exercise programme, consisting of aerobic and resistance-based sets, can be safely delivered to people living with PBC. In addition, the programme led to a reduction in fatigue severity, less daytime sleepiness and improved cognitive function.
Authors
- Matthew J. Armstrong (ORCID: https://orcid.org/0000-0002-3425-1161)
- Alice Freer
- Palak Trivedi (ORCID: https://orcid.org/0000-0002-4009-8087)
- Felicity Williams (ORCID: https://orcid.org/0000-0001-5189-4073)
- Simon Durman
- Jennifer Hayden
Institutions
- Queen Elizabeth Hospital Birmingham (GB)
- NIHR Birmingham Liver Biomedical Research Unit (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101210
- Citations
- 8
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 2.96
Funders
- Intercept Pharmaceuticals