Imlunestrant, an Oral Selective Estrogen Receptor Degrader, as Monotherapy and in Combination With Targeted Therapy in Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer: Phase Ia/Ib EMBER Study
Imlunestrant, as monotherapy or in combination with targeted therapy, had a manageable safety profile with evidence of preliminary antitumor activity in ER+/HER2- ABC.
Authors
- Erika Hamilton (ORCID: https://orcid.org/0000-0002-1911-0336)
- J. Thaddeus Beck (ORCID: https://orcid.org/0000-0002-3341-9903)
- Manali Ajay Bhave
- Timothy Larson (ORCID: https://orcid.org/0009-0001-8921-6857)
- Patrick Neven (ORCID: https://orcid.org/0000-0002-1434-9460)
- Yen‐Shen Lu (ORCID: https://orcid.org/0000-0001-7461-1291)
- Muralidhar Beeram
- Ajay Dhakal (ORCID: https://orcid.org/0000-0002-5140-158X)
- Sarah Sammons (ORCID: https://orcid.org/0000-0003-2589-9422)
- Peter A. Kaufman (ORCID: https://orcid.org/0000-0003-3677-6807)
- Jean‐Yves Pierga (ORCID: https://orcid.org/0000-0002-2863-9995)
- Roohi Ismail‐Khan (ORCID: https://orcid.org/0000-0002-1301-6736)
- Bastien Nguyen (ORCID: https://orcid.org/0000-0002-6166-4746)
- Kan Yonemori (ORCID: https://orcid.org/0000-0002-7624-7611)
- Yolanda Jerez (ORCID: https://orcid.org/0000-0001-5129-0747)
- Sung‐Bae Kim (ORCID: https://orcid.org/0000-0001-5588-8332)
- Joohyuk Sohn (ORCID: https://orcid.org/0000-0002-2303-2764)
- Aditya Bardia (ORCID: https://orcid.org/0000-0003-4885-1157)
- Cynthia X. Ma (ORCID: https://orcid.org/0000-0002-8156-7492)
- Shawn T. Estrem
- Luís Manso (ORCID: https://orcid.org/0000-0002-1683-550X)
- Komal L. Jhaveri (ORCID: https://orcid.org/0000-0003-0472-1254)
- Kathleen Harnden (ORCID: https://orcid.org/0000-0002-8211-708X)
- Kostandinos Sideras (ORCID: https://orcid.org/0000-0002-4698-2105)
- Rinath M. Jeselsohn (ORCID: https://orcid.org/0000-0001-7996-7529)
- Eunice Yuen (ORCID: https://orcid.org/0000-0003-2145-6368)
- Seock‐Ah Im (ORCID: https://orcid.org/0000-0002-5396-6533)
- Jessica J. Tao (ORCID: https://orcid.org/0000-0002-6532-4466)
- Philippe Aftimos (ORCID: https://orcid.org/0000-0001-9946-4726)
- Cynthia R. Osborne (ORCID: https://orcid.org/0000-0001-8040-4985)
- Vanessa Rodrik-Outmezguine (ORCID: https://orcid.org/0000-0002-3024-4490)
- Cristina Saura (ORCID: https://orcid.org/0000-0001-8296-5065)
- Elgene Lim (ORCID: https://orcid.org/0000-0001-8065-8838)
- Lillian M. Smyth (ORCID: https://orcid.org/0000-0002-0986-9285)
- Yujia Li (ORCID: https://orcid.org/0000-0002-1024-9243)
- Hwei-Chung Wang
- Francesca Bacchion
- Ritesh Parajuli
Institutions
- University of Vermont (US)
- Ulsan College (KR)
- McKesson (United States) (US)
- Université Libre de Bruxelles (BE)
- Memorial Sloan Kettering Cancer Center (US)
- Garvan Institute of Medical Research (AU)
- Johns Hopkins University (US)
- Emory University (US)
- Eli Lilly (United States) (US)
- China Medical University (TW)
- Yonsei University (KR)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- Université Paris Cité (FR)
- Cornell University (US)
- Severance Hospital (KR)
- Texas Oncology (US)
- Universitair Ziekenhuis Leuven (BE)
- Jacksonville College (US)
- Asan Medical Center (KR)
- Institut Jules Bordet (BE)
- WinnMed (US)
- Seoul National University Hospital (KR)
- University of Rochester Medical Center (US)
- Hospital General Universitario Gregorio Marañón (ES)
- UNSW Sydney (AU)
- University of Ulsan (KR)
- Massachusetts General Hospital (US)
- Virginia Cancer Institute (US)
- Sarah Cannon (US)
- Hospital Universitario 12 De Octubre (ES)
- Highlands Oncology Group (US)
- Dana-Farber Cancer Institute (US)
- South Texas Accelerated Research Therapeutics (US)
- St Vincent's Clinic (AU)
- Duke Medical Center (US)
- China Medical University Hospital (TW)
- Vall d'Hebron Hospital Universitari (ES)
- National Taiwan University Hospital (TW)
- Tennessee Oncology (US)
- Center for Health Care Services (US)
- Mayo Clinic in Florida (US)
- The US Oncology Network (US)
- Tokyo National Hospital (JP)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Minnesota Oncology (US)
- Vall d'Hebron Institute of Oncology (ES)
- Institut Curie (FR)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1200/jco.23.02733
- Citations
- 31
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 12.99
Funders
- Eli Lilly and Company
- Memorial Sloan-Kettering Cancer Center