Delineating the relationship between circulating osteoprotegerin and bone health in women with a pathogenic variant in BRCA1: A cross-sectional analysis
Our findings suggest that women with inherently lower OPG may be at risk of lower BMD, the gold standard marker of bone disease. Due to the young age of our cohort, on-going studies are warranted to re-evaluate the association between OPG and FRAX in <i>BRCA</i> mutation carriers.
Authors
- Angela M. Cheung (ORCID: https://orcid.org/0000-0001-8332-0744)
- Jan Lubiński (ORCID: https://orcid.org/0000-0003-2931-3003)
- Leonardo Salmena (ORCID: https://orcid.org/0000-0003-4023-658X)
- Aleksandra Uzelac
- Joanne Kotsopoulos (ORCID: https://orcid.org/0000-0001-9624-4218)
- Steven A. Narod (ORCID: https://orcid.org/0000-0001-5798-0626)
- Elizabeth Hall
- Aghaghia Mokhber
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Queen's University (CA)
- Women's College Hospital (CA)
- Public Health Ontario (CA)
- Osteoporosis Canada (CA)
- Pomeranian Medical University (PL)
Publication Details
- Journal
- Bone Reports
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.bonr.2024.101802
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canada Excellence Research Chairs, Government of Canada
- Canadian Institutes of Health Research
- Canadian Cancer Society Research Institute
- Institute of Genetics