Identification of key genes and pathways involved in T-DM1-resistance in OE-19 esophageal cancer cells through bioinformatics analysis
This comprehensive bioinformatics analysis deeply explains the molecular mechanisms governing TDM-1 resistance in EC. The identified hub genes and their associated pathways offer potential targets for therapeutic interventions. Moreover, the possible role of NSAIDs in mitigating T-DM1 resistance presents an intriguing avenue for further investigation. This research contributes significantly to the field and establishes a basis for further research to enhance treatment efficacy for EC patients.
Authors
- Abozar Ghorbani (ORCID: https://orcid.org/0000-0002-2183-0033)
- Hamed Montazeri (ORCID: https://orcid.org/0000-0001-8532-4327)
- Pietro Hiram Guzzi (ORCID: https://orcid.org/0000-0001-5542-2997)
- Khadijeh Ahmadi (ORCID: https://orcid.org/0000-0002-2289-9710)
- Behzad Shahbazi (ORCID: https://orcid.org/0000-0002-0903-2960)
- Negar Mottaghi-Dastjerdi (ORCID: https://orcid.org/0000-0001-8386-774X)
- Fateme Yazdani
- Mohammad Soltany‐Rezaee‐Rad (ORCID: https://orcid.org/0000-0002-0663-1140)
- Farzane Khoshdel
Institutions
- Atomic Energy Organization of Iran (IR)
- Iran University of Medical Sciences (IR)
- Magna Graecia University (IT)
- Hormozgan University of Medical Sciences (IR)
- Semnan University of Medical Sciences (IR)
- Farzan Knowledge Development, Research and Technology Institute (IR)
- Nuclear Science and Technology Research Institute
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37451
- Citations
- 9
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- Iran University of Medical Sciences