Correlation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with serum α-klotho levels in US middle-aged and older individuals: Results from NHANES 2007–2016
Our study revealed a significant negative relationship between inflammatory markers (NLR and PLR) and serum αKl levels, suggesting systemic inflammation may be linked to reduced αKl expression. Subgroup analyses showed that the relationship varies across different demographic and health-related factors. We provided insight into the significance of managing inflammation and preserving αKl levels.
Authors
- Lei Guan (ORCID: https://orcid.org/0000-0003-1177-3052)
- WenHong Gao
- Xiaoyan Tang (ORCID: https://orcid.org/0009-0004-3628-5228)
- Zili Chen (ORCID: https://orcid.org/0000-0002-0473-6395)
- Wei Huang (ORCID: https://orcid.org/0000-0002-7279-0932)
- Rui Du (ORCID: https://orcid.org/0000-0002-1307-4098)
- Jie Liu (ORCID: https://orcid.org/0009-0006-5054-4550)
Institutions
- Central Hospital of Wuhan (CN)
- Wuhan General Hospital of Guangzhou (CN)
- Inner Mongolia International Mongolian Hospital (CN)
Publication Details
- Journal
- Preventive Medicine Reports
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1016/j.pmedr.2024.102877
- Citations
- 2
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.57