A study on the methylation patterns of DIO3 in patients with heart failure and its correlation with key clinical parameters
The methylation level of <i>DIO3</i>_FA26_CpG_17.18 is significantly reduced in patients with HF, and that of <i>DIO3</i>_FA26_CpG_24.25.26.27 is significantly decreased in patients with III/IV cardiac function. Variations in <i>DIO3</i>_FA26 methylation levels influence coagulation, liver and kidney functions, and routine blood indexes, including D-dimer, albumin, calcium, and hemoglobin. This study provides clinical evidence for the involvement of <i>DIO3</i>_FA26 methylation in the occurrence and development of HF and proposes novel targets for HF prevention and treatment.
Authors
- Chuanyong Qu (ORCID: https://orcid.org/0000-0002-7249-9440)
- Min Zhang (ORCID: https://orcid.org/0000-0001-5812-9518)
- Rongqiang Zhang (ORCID: https://orcid.org/0000-0003-3351-2128)
- Qi Miao (ORCID: https://orcid.org/0000-0002-4500-8140)
- Aoyue He
Institutions
- Ningxia Hui Autonomous Region Peoples Hospital (CN)
- Affiliated Hospital of Shaanxi University of Chinese Medicine (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37582
- Citations
- 2
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.80