Effectiveness of saffron in the treatment of mild to moderate Alzheimer’s disease with ADAS-cog score

Introduction: large levels of glucocorticoids and stress results structural and functional changes in brain and hippocampus, limbic system has a key role in cognitive functions including learning and memory. Alzheimer’s disease (AD) is a chronic neurodegenerative disease. Objective: the AIM of this study was to assess the efficacy of saffron in the treatment of mild to moderate Alzheimer’s disease (AD). Methods: fifty-six patients of 55 years old were eligible to participate in this study. the study is a double-blind study of parallel groups of patients with AD. Results: saffron is effective similar to donepezil in the treatment of mild to moderate AD after 22 weeks. The safety of saffron is comparatively similar like donepezil. The side effects presented with saffron and donepezil groups likely same. The major parameter taken was Alzheimer’s disease assessment Scale-cognitive subscale score evaluated with baseline. The safety of saffron was also recorded systemically. Participators were given a capsule saffron 30 mg/day (15 mg twice daily) or donepezil 10 mg/day (5 mg twice per day). Conclusion: this study provides mainly suggests that possible therapeutic effect of saffron extract at least in short-term treatment of patients with mild-to0moderate Alzheimer’s disease.