Population Pharmacokinetic Modeling of Pyrazinamide Among Chinese Patients With Drug-Sensitive or Multidrug-Resistant Tuberculosis
Fixed pyrazinamide doses of 1500, 1750, and 2000 mg are recommended for patients weighing 40-70, 70-80, and 80-90 kg, respectively, to achieve the exposure targets of AUC 0-24 > 363 mg·h/L or C max > 35 mg/L to attain efficacy.
Authors
- Weiqiao Rao (ORCID: https://orcid.org/0000-0001-8624-6703)
- Guofang Deng (ORCID: https://orcid.org/0000-0003-2479-3327)
- Jin Zou
- Jiancong Zhang
- Jiuxin Qu (ORCID: https://orcid.org/0000-0003-1061-2353)
- Liang Lin (ORCID: https://orcid.org/0000-0001-7374-7234)
- Liang Fu (ORCID: https://orcid.org/0000-0003-1112-8010)
- Lujin Li (ORCID: https://orcid.org/0000-0003-2923-3206)
- Yunli Liao
- Shi-Jin Yang
- Siqi Liu (ORCID: https://orcid.org/0000-0001-9744-3681)
- Guohui Liu (ORCID: https://orcid.org/0000-0002-2013-1396)
- Shuyan Chen (ORCID: https://orcid.org/0000-0003-4148-8703)
- Ning Lv
Institutions
- BGI Group (China) (CN)
- Southern University of Science and Technology (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- University of Chinese Academy of Sciences (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2024-09-06
- DOI
- https://doi.org/10.1097/ftd.0000000000001255
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00