Investigating the relationship between thalamic iron concentration and disease severity in secondary progressive multiple sclerosis using quantitative susceptibility mapping: Cross-sectional analysis from the MS-STAT2 randomised controlled trial
The reduced thalamic susceptibility found in SPMS compared to controls suggests that thalamic iron concentrations are lower at this advanced stage of the disease. The observed relationships between lower thalamic susceptibility and more severe physical, cognitive and visual disability suggests that reductions in thalamic iron may correlate with important mechanisms of clinical disease progression. Such mechanisms appear to intimately link reductions in thalamic iron with higher T2LV and the development of thalamic atrophy, encouraging further research into QSM-derived thalamic susceptibility as a biomarker of disease severity in SPMS.
Authors
- Karin Shmueli (ORCID: https://orcid.org/0000-0001-7520-2975)
- Jeremy Chataway (ORCID: https://orcid.org/0000-0001-7286-6901)
- Olga Ciccarelli (ORCID: https://orcid.org/0000-0003-0638-1660)
- Anisha Doshi (ORCID: https://orcid.org/0000-0001-6699-8668)
- Nevin John (ORCID: https://orcid.org/0000-0002-9834-4498)
- Anita Karsa (ORCID: https://orcid.org/0000-0002-8648-3853)
- Thomas Williams (ORCID: https://orcid.org/0000-0002-8197-0177)
- Claudia A. M. Gandini Wheeler‐Kingshott (ORCID: https://orcid.org/0000-0002-4832-1300)
- Francesco Grussu (ORCID: https://orcid.org/0000-0002-0945-3909)
- Marios Yiannakas (ORCID: https://orcid.org/0000-0003-4986-446X)
- Floriana De Angelis (ORCID: https://orcid.org/0000-0002-9833-1435)
- Fatima Chowdhury (ORCID: https://orcid.org/0000-0002-2013-5370)
- Ferrán Prados (ORCID: https://orcid.org/0000-0002-7872-0142)
- Madiha Shatila
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Alberto Calvi (ORCID: https://orcid.org/0000-0002-1953-2803)
- Alessia Bianchi (ORCID: https://orcid.org/0000-0001-5541-5818)
- Marco Battiston (ORCID: https://orcid.org/0000-0003-2231-2251)
- David MacManus (ORCID: https://orcid.org/0000-0002-0902-977X)
- Sarah Wright (ORCID: https://orcid.org/0000-0002-1146-1801)
- Antonio Ricciardi (ORCID: https://orcid.org/0009-0001-7461-051X)
- Becky Samson
- Jon Stutters
Institutions
- Universitat Oberta de Catalunya (ES)
- Queen Mary University of London (GB)
- University of Pavia (IT)
- National Institute for Health and Care Research (GB)
- MRC Clinical Trials Unit at UCL (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Monash University (AU)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Neuroimage Reports
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.ynirp.2024.100216
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- National Multiple Sclerosis Society
- Biogen
- Teva Pharmaceutical Industries
- Prothena
- National Institute for Health and Care Research
- Multiple Sclerosis Society
- University College London
- Rosetrees Trust
- Eisai
- University College London Hospitals NHS Foundation Trust
- IXICO
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- Medical Research Council