Design and Development of Long-Term Therapy for Corneal Repair and Healing – ‘Nanoparticles-in-Dual-Gels’
Objective: We aimed to develop a dual-gel cocktail therapy that would fill the treatment gap with safety and patient adherence in lieu of invasive procedures for corneal wound management and self-healing. For this, PLGA-PPS-based nanoparticles (NPs)-loaded with dexamethasone (DEX), and rapamycin (RAPA) are embedded in the stimuli-responsive dual-gels assembly, that consists of thermo-responsive poloxamer (trPol) and photo-responsive gelatin methyl acrylate (prGelMa)- based hydrogels for long-term drug release.
Authors
- Neeraj S. Thakur (ORCID: https://orcid.org/0000-0003-1758-0737)
- Brototi Chakrabarty
- Vibhuti Agrahari (ORCID: https://orcid.org/0000-0003-1884-1644)
- Kate A. Montreuil
- Brooke T. Robbins
Institutions
- University of Oklahoma (US)
Publication Details
- Journal
- American Journal of Pharmaceutical Education
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.ajpe.2024.100918
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00