Short-Term and Long-Term Fluvastatin Inhibit Effects of Thrombospondin-1 on Human Vascular Smooth Muscle Cells
Long-term fluvastatin inhibited thrombospondin-1-induced chemotaxis through the mevalonate pathway while short-term fluvastatin inhibited chemotaxis through an alternate mechanism. Short-term stains have immediate effects independent of the mevalonate pathway. Acute local treatment with statins followed by longer term therapy may limit the vascular response to injury.
Authors
- Boris Ryabtsev (ORCID: https://orcid.org/0000-0001-9541-1619)
- Chinenye Iwuchukwu
- Alex Helkin
- Keri A. Seymour (ORCID: https://orcid.org/0000-0002-2735-0786)
- Jeffrey J. Stein
- Vivian Gahtan (ORCID: https://orcid.org/0000-0003-3602-4904)
- Kristopher G. Maier (ORCID: https://orcid.org/0000-0003-0987-4751)
- Helen L. Yuan
Institutions
- Loyola University Chicago (US)
- SUNY Upstate Medical University (US)
- Syracuse VA Medical Center (US)
Publication Details
- Journal
- Vascular and Endovascular Surgery
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1177/15385744241279113
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Institutes of Health