Beneficial adjunctive effects of the 5HT3 receptor antagonist ondansetron on symptoms, function and cognition in early phase schizophrenia in a double-blind, 2 × 2 factorial design, randomised controlled comparison with simvastatin
Small improvement in negative symptoms on simvastatin and ondansetron individually are not synergistic in combination in treating negative symptoms of schizophrenia. Ondansetron showed broad efficacy in patients on stable antipsychotic treatment within 5 years of illness. The findings suggest that ondansetron should be evaluated in patients at risk of psychosis or early in treatment.
Authors
- Ameer B. Khoso (ORCID: https://orcid.org/0000-0003-2026-7952)
- J.F.W. Deakin (ORCID: https://orcid.org/0000-0002-2750-962X)
- Nusrat Husain
- Inti Qurashi (ORCID: https://orcid.org/0000-0002-3177-5947)
- Muhammad Omair Husain (ORCID: https://orcid.org/0000-0002-8575-3364)
- Raza-Ur Rahman (ORCID: https://orcid.org/0000-0001-8064-898X)
- Imran B. Chaudhry (ORCID: https://orcid.org/0000-0001-7493-7515)
- Tayyeba Kiran (ORCID: https://orcid.org/0000-0003-2478-4148)
- Muhammad Ishrat Husain (ORCID: https://orcid.org/0000-0001-5771-5750)
- Richard Drake (ORCID: https://orcid.org/0000-0003-0220-4835)
- Nasir Mehmood (ORCID: https://orcid.org/0000-0002-0229-7966)
Institutions
- Centre for Addiction and Mental Health (CA)
- University of Liverpool (GB)
- University of Toronto (CA)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Dow University of Health Sciences (PK)
- Mersey Care NHS Trust (GB)
- Pakistan Institute of Learning and Living (PK)
- Ziauddin University (PK)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1177/02698811241267836
- Citations
- 5
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Stanley Medical Research Institute
- University of Toronto
- Department of Psychiatry, University of Toronto