A male-specific mechanism of meningeal nociceptor sensitization promoting migraine headache
Our studies reveal a male-specific mechanism of TG nociceptor sensitization and migraine-like pain behavior mediated by orexin B/OX2R signaling. Sexually dimorphic mechanisms of trigeminal nociceptor sensitization and activation offer opportunities to improve patient outcomes by considering patient sex and may influence clinical trial design and interpretation.
Authors
- Kara R. Barber (ORCID: https://orcid.org/0000-0002-4042-9886)
- David W. Dodick (ORCID: https://orcid.org/0000-0002-9486-6790)
- Edita Navratilova (ORCID: https://orcid.org/0000-0002-1497-125X)
- Frank Porreca (ORCID: https://orcid.org/0000-0002-2267-0617)
- Aubin Moutal (ORCID: https://orcid.org/0000-0003-4268-1206)
- Grace Lee (ORCID: https://orcid.org/0000-0001-7892-2871)
- Caroline Machado Kopruszinski (ORCID: https://orcid.org/0000-0002-5392-5117)
- Laurent K. Martin
Institutions
- University of Arizona (US)
- Mayo Clinic Hospital (US)
- Saint Louis University (US)
Publication Details
- Journal
- Cephalalgia
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1177/03331024241281493
- Citations
- 10
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.86
Funders
- National Institutes of Health