A novel<i>in vitro</i>tubular model to recapitulate features of distal airways: the bronchioid
Here, we provide a proof of concept of a perfusable bronchioid with proper mucociliary and contractile functions. The key advantages of our approach, such as the air‒liquid interface, lumen accessibility, recapitulation of pathological features and possible assessment of clinically relevant end-points, will make our pulmonary organoid-like model a powerful tool for preclinical studies.
Authors
- Alexander M. Leipold (ORCID: https://orcid.org/0000-0002-9471-3276)
- Isabelle Dupin (ORCID: https://orcid.org/0000-0002-4992-9625)
- Gaëlle Recher (ORCID: https://orcid.org/0000-0001-9004-0118)
- M. Zysman (ORCID: https://orcid.org/0000-0003-1459-2409)
- Laëtitia Andrique (ORCID: https://orcid.org/0000-0001-7840-8135)
- Matthieu Thumerel (ORCID: https://orcid.org/0000-0003-4673-8433)
- Tobias Krammer (ORCID: https://orcid.org/0000-0002-7638-9476)
- Pauline Henrot (ORCID: https://orcid.org/0000-0002-6528-6092)
- Pierre Nassoy (ORCID: https://orcid.org/0000-0003-4615-9431)
- Renaud Prével
- Antoine‐Emmanuel Saliba (ORCID: https://orcid.org/0000-0001-8539-2784)
- Patrick Berger (ORCID: https://orcid.org/0000-0003-4702-0343)
- Élise Maurat (ORCID: https://orcid.org/0000-0002-9400-0815)
- Thomas Trian (ORCID: https://orcid.org/0000-0002-2567-4867)
- Katharina Raasch
- Vanessa Bergeron (ORCID: https://orcid.org/0009-0000-0401-9735)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Universitaire de France (FR)
- University of Würzburg (DE)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Bordeaux Population Health (FR)
- Equilibrium Research (GB)
- Helmholtz Institute for RNA-based Infection Research (DE)
- Laboratoire Photonique, Numérique et Nanosciences (FR)
- Centre de Recherche Cardio-Thoracique de Bordeaux (FR)
- TBM-Core
- Centre d'Investigation Clinique Plurithématique de Bordeaux
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2024-09-04
- DOI
- https://doi.org/10.1183/13993003.00562-2024
- Citations
- 14
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 5.87
Funders
- Agence Nationale de la Recherche
- Institut Universitaire de France
- Université de Bordeaux