Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway
These findings indicate that quercetin can inhibit apoptosis in GCs and restore ovarian function by activating autophagy through the SIRT1/ROS/AMPK signaling pathway, suggesting a new direction for the treatment of ovarian follicular cysts in high-yield dairy cows.
Authors
- Xianghong Du (ORCID: https://orcid.org/0000-0003-1383-3565)
- Hongwei Duan (ORCID: https://orcid.org/0000-0002-2970-6344)
- Fang Wang (ORCID: https://orcid.org/0000-0001-8752-8139)
- Junjie Hu (ORCID: https://orcid.org/0000-0003-2522-4724)
- Xiaofei Ma (ORCID: https://orcid.org/0000-0001-7041-934X)
- Lihong Zhang (ORCID: https://orcid.org/0000-0003-0183-3517)
- Ke Wang (ORCID: https://orcid.org/0000-0001-9865-0877)
- Xue Chen (ORCID: https://orcid.org/0000-0001-7537-1525)
- Jian Kang (ORCID: https://orcid.org/0000-0001-5235-7990)
- Shuai Yang (ORCID: https://orcid.org/0000-0002-1353-2941)
- Xingxu Zhao (ORCID: https://orcid.org/0000-0002-2357-6139)
- Longfei Xiao (ORCID: https://orcid.org/0000-0002-6251-9161)
- Rong Zhang (ORCID: https://orcid.org/0000-0002-0917-0079)
- Yong Zhang
Institutions
- Gansu Agricultural University (CN)
- Guangdong Polytechnic of Science and Technology (CN)
- Gansu Provincial Agriculture and Animal Husbandry (CN)
- Beijing University of Agriculture (CN)
- Qingdao Institute of Animal Husbandry and Veterinary Medicine (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1186/s40104-024-01078-5
- Citations
- 26
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 14.12
Funders
- National Natural Science Foundation of China
- Beijing University of Agriculture
- Science and Technology Department of Gansu Province