Pharmacokinetic and Pharmacodynamic Assessment of Valganciclovir in Infants With Congenital Cytomegalovirus Infection
The relationship between neutrophil count and ganciclovir trough concentration in infants was clarified. The PPK model showed that the dose of VGCV should be reduced in patients with a low PMA to achieve target exposure.
Authors
- Mari Hashimoto
- Kotaro Itohara (ORCID: https://orcid.org/0000-0002-7982-7881)
- Kazuhiro Yamamoto (ORCID: https://orcid.org/0000-0002-7513-6725)
- Naoki Tamura (ORCID: https://orcid.org/0000-0002-9040-5612)
- Shunsuke Fujinaka
- Tomohiro Omura (ORCID: https://orcid.org/0000-0001-5520-253X)
- Kazumichi Fujioka (ORCID: https://orcid.org/0000-0002-9913-6447)
- Yumi Kitahiro (ORCID: https://orcid.org/0000-0002-0263-5726)
- Ikuko Yano (ORCID: https://orcid.org/0000-0001-9517-5628)
Institutions
- Kobe Pharmaceutical University (JP)
- Kobe University Hospital (JP)
- Kobe University (JP)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2024-09-04
- DOI
- https://doi.org/10.1097/ftd.0000000000001257
- Citations
- 4
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Japan Agency for Medical Research and Development