Silver Nanoparticles (AgNPs) Uptake by Caveolae-Dependent Endocytosis is Responsible for Their Selective Effect Towards Castration Resistant Prostate Cancer
This study shows the potential of these AgNPs as a new therapeutic approach directed to CRPC patients, uncovers caveolae-dependent endocytosis as the uptake mechanism of these AgNPs and highlights deregulation of Cav1 and Cav2 expression as a key difference in hormone sensitive and resistant PCa cells which may be responsible for drug resistance.
Authors
- Ana Luísa Teixeira (ORCID: https://orcid.org/0000-0002-7489-2211)
- Rui Medeiros (ORCID: https://orcid.org/0000-0003-3010-8373)
- Francisca Dias (ORCID: https://orcid.org/0000-0002-4993-4467)
- Mariana Morais (ORCID: https://orcid.org/0000-0001-8406-8210)
- Manuel R. Teixeira (ORCID: https://orcid.org/0000-0002-4896-5982)
- Patrícia Figueiredo (ORCID: https://orcid.org/0000-0002-3689-3280)
- Carla Escudeiro (ORCID: https://orcid.org/0000-0002-8809-4894)
- Johnny Lisboa (ORCID: https://orcid.org/0000-0001-7329-8993)
- Kirsi S. Mikkonen (ORCID: https://orcid.org/0000-0003-4490-5912)
- Inês Ferreira Dias Tavares (ORCID: https://orcid.org/0000-0002-9738-6178)
- Alexandra Teixeira (ORCID: https://orcid.org/0000-0001-7679-0529)
Institutions
- University of Helsinki (FI)
- Fernando Pessoa University (PT)
- Universidade do Porto (PT)
- Portuguese League Against Epilepsy (PT)
- Instituto Português de Oncologia Francisco Gentil (PT)
- IPO Porto (PT)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/ijn.s447645
- Citations
- 15
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 2.60
Funders
- Fundação para a Ciência e a Tecnologia
- European Regional Development Fund