Proteomics of severe SARS-COV-2 infection and paraquat poisoning in human lung tissue samples: comparison of microbial infected and toxic pulmonary fibrosis
This study illuminates distinct protein-level differences by investigating pulmonary fibrosis pathways in severe COVID-19 and paraquat poisoning. Although both conditions activate lung-protective and repair pathways, COVID-19 shows limited phosphorylation-independent ubiquitination of β-catenin compared to paraquat toxicity. These findings shed light on potential therapeutic targets for PF induced via diverse factors.
Authors
- Yiwu Zhou (ORCID: https://orcid.org/0000-0002-6061-6769)
- Liang Ren (ORCID: https://orcid.org/0000-0003-2705-4669)
- Min Jiang (ORCID: https://orcid.org/0000-0003-1530-6830)
- Qian Liu (ORCID: https://orcid.org/0000-0001-8525-7961)
- Xiang Liu (ORCID: https://orcid.org/0000-0002-9541-0541)
- Shujuan Wang (ORCID: https://orcid.org/0000-0001-8495-3703)
- Liang Liu (ORCID: https://orcid.org/0000-0002-8437-5998)
- Hou Jiaqi
- Chai Qianqian
- Lin Lihua
Institutions
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.3389/fcimb.2024.1446305
- Citations
- 3
- Primary Topic
- Paraquat toxicity studies and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Natural Science Foundation of Hubei Province
- Fundamental Research Funds for the Central Universities