The Impact of HLA-DQαβ Heterodimer Mismatch on Living Donor Kidney Allograft Outcomes
HLA-DQαβ allele mismatch predicted allograft rejection even when controlling for HLA-DR antigen mismatch and were both independently associated with increased risk of graft failure or rejection in adult living kidney transplant recipients. Given the strong burden of disease arising from the HLA-DQ antibody formation, we suggest that HLA-DQαβ should be prioritized over HLA-DR in donor selection.
Authors
- Gerald P. Morris (ORCID: https://orcid.org/0000-0002-1097-4453)
- Allan B. Massie (ORCID: https://orcid.org/0000-0002-5288-5125)
- Dorry Lidor Segev (ORCID: https://orcid.org/0000-0002-1924-4801)
- Andrew M. Hallett
- Eszter Lázár‐Molnár (ORCID: https://orcid.org/0000-0003-0802-9409)
- John L. Schmitz (ORCID: https://orcid.org/0000-0002-1425-236X)
- Olga Timofeeva (ORCID: https://orcid.org/0000-0002-9886-6683)
- Tanveen Ishaque (ORCID: https://orcid.org/0000-0002-3523-243X)
- Olga Charnaya (ORCID: https://orcid.org/0000-0003-1104-2882)
- Anat R. Tambur (ORCID: https://orcid.org/0000-0002-0320-9825)
- Scott M. Krummey (ORCID: https://orcid.org/0000-0002-7504-9162)
- Luis Hidalgo (ORCID: https://orcid.org/0000-0002-9959-0658)
- Myra Coppage
- Aiwen Zhang (ORCID: https://orcid.org/0000-0001-5573-4026)
Institutions
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- Johns Hopkins University (US)
- Thomas Jefferson University (US)
- University of Utah (US)
- Johns Hopkins Medicine (US)
- University of California San Diego (US)
- University of Rochester (US)
Publication Details
- Journal
- Transplantation
- Published
- 2024-09-05
- DOI
- https://doi.org/10.1097/tp.0000000000005198
- Citations
- 7
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.56