ALKBH5‐mediated m<sup>6</sup>A demethylation ameliorates extracellular matrix deposition in cutaneous pathological fibrosis
Our study identified ALKBH5 as an endogenous suppressor of pathological ECM deposition, contributing to the development of a reprogrammed m6A-targeted therapy for HTSs.
Authors
- Yimin Khoong (ORCID: https://orcid.org/0000-0003-4748-9213)
- Ruoqing Xu (ORCID: https://orcid.org/0009-0006-1233-4026)
- Hsin Liang
- Shenying Luo (ORCID: https://orcid.org/0000-0002-5696-7929)
- Yixuan Zhao
- En Yang (ORCID: https://orcid.org/0000-0001-9400-9644)
- Tao Zan (ORCID: https://orcid.org/0000-0002-4810-9668)
- Haizhou Li (ORCID: https://orcid.org/0000-0003-0629-0777)
- Xin Huang (ORCID: https://orcid.org/0000-0001-9430-5558)
- Yunhan Liu (ORCID: https://orcid.org/0000-0002-5531-2357)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/ctm2.70016
- Citations
- 7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation