β‐1,4‐Galactosyltransferase 1 protects against cerebral ischemia injury in mice by suppressing ferroptosis via the <scp>TAZ</scp>/Nrf2/<scp>HO</scp>‐1 signaling pathway
The results indicated that rh-B4galt1 implements neuroprotective effects by modulating ferroptosis, primarily via upregulating TAZ/Nrf2/HO-1 pathway. Thus, B4galt1 could be seen as a promising novel objective for ischemic stroke therapy.
Authors
- Peng Wang (ORCID: https://orcid.org/0000-0001-9660-0147)
- Lili Ren (ORCID: https://orcid.org/0000-0003-2623-0579)
- Jia Liang (ORCID: https://orcid.org/0000-0001-7311-1260)
- Yunhao Xu (ORCID: https://orcid.org/0000-0003-4650-6616)
- Chang Liu (ORCID: https://orcid.org/0000-0002-9306-2475)
- Jiachen Li (ORCID: https://orcid.org/0000-0001-9054-1975)
- Yao Ma (ORCID: https://orcid.org/0000-0002-0561-2482)
Institutions
- Jinzhou Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1111/cns.70030
- Citations
- 9
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province