Casual effects of type 1 diabetes mellitus on site-specific digestive cancers: a Mendelian randomisation analysis
In this MR study with a large number of digestive cancer cases, we found no evidence to support the causal role of T1DM in the risk of oesophageal cancer, stomach cancer, hepatocellular carcinoma, biliary tract cancer, or pancreatic cancer. However, we found a causal positive association between T1DM and colorectal cancer. Further large-scale prospective studies are necessary to replicate our findings.
Authors
- Jinli Zhao
- Libo Chen (ORCID: https://orcid.org/0000-0001-5787-580X)
- Mingyong Li (ORCID: https://orcid.org/0000-0003-3519-5373)
- Wenjin Li (ORCID: https://orcid.org/0000-0002-4555-5857)
- Weiming Deng (ORCID: https://orcid.org/0000-0003-4329-5059)
Institutions
- First Affiliated Hospital of University of South China (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-09-05
- DOI
- https://doi.org/10.3389/fendo.2024.1407329
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.85